Status:
UNKNOWN
The Effect of Preoperative Antibiotics on Peri-implant Healing
Lead Sponsor:
Université de Montréal
Collaborating Sponsors:
Centre de Recherche du Centre Hospitalier de l'Université de Montréal
Conditions:
Dental Implant Failed
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Introduction: In order to minimize postoperative morbidity and failures of dental implant therapy, several antibiotic regimens have been proposed in the literature. However, the extensive use of antib...
Detailed Description
Background There have been many antibiotic regimens used to minimize the risks of infections and consequently, increasing the survival rate of dental implants. Initially, it was recommended to give a...
Eligibility Criteria
Inclusion
- Periodontally healthy remaining dentition or presenting with mild gingivitis with adequate oral hygiene.
- Presence of a partially edentulous alveolar ridge that is planned to be restored with no more than 2 implants.
- To have 1 or 2 implants restored with a crown or fixed bridge.
- Presence of a non-infected site.
- Presence of enough bone and soft tissue for the implant to be placed without additional bone augmentation in a 1-stage approach (with healing abutment).
- Implants 6 mm long or longer.
- Subjects able and willing to provide written informed consent and comply with study procedures.
Exclusion
- Subjects taking regular analgesics or antidepressants.
- Smoking 10 cigarettes/cigars or more per day.
- Marijuana smokers.
- Use of vaping devices or e-cigarettes
- Drug abuse.
- Completely edentulous individuals.
- Pregnant and nursing women.
- Allergies to macrolides, and/or non-steroidal anti-inflammatory analgesics.
- Active peptic ulcers or susceptibility to peptic ulcers.
- Any systemic or local immunodeficiency.
- Any blood coagulation impairment or taking anticoagulants (ex.: Coumadin).
- Presence of uncontrolled periodontitis or poor oral hygiene.
- Presence of any acute oral infection.
- Presence of uncontrolled diabetes or other systemic diseases.
- Previous radiation therapy in the head and neck area.
- Intravenous bisphosphonates.
- Oral bisphosphonates intake for more than 4 years.
- Long-term intake of corticosteroids.
- Need for routine prophylactic antibiotics prior dental surgery.
- No intake of antibiotics 3 months prior surgery.
Key Trial Info
Start Date :
February 25 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2023
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04280406
Start Date
February 25 2020
End Date
December 1 2023
Last Update
September 7 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Université de Montréal - Faculty of Dentistry - Dental clinics
Montreal, Quebec, Canada, H3T 1J4