Status:
COMPLETED
Symptomatic Trial of Angina Assessment Prior to Revascularization
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
Imperial College Healthcare NHS Trust
Mid and South Essex NHS Foundation Trust
Conditions:
Coronary Artery Disease
Angina, Stable
Eligibility:
All Genders
18-85 years
Brief Summary
The principal objective of this research is to determine whether symptoms, induced by confirmed experimental ischaemia, can help us predict which patients will respond to PCI.
Eligibility Criteria
Inclusion
- Angina or angina-equivalent symptoms
- Anatomical evidence of a significant single vessel coronary stenosis on diagnostic coronary angiography indicating ≥ 70% stenosis
- Referred for percutaneous coronary intervention for treatment of stable angina
Exclusion
- Age younger than 18
- Age older than 85
- Recent acute coronary syndrome
- Multivessel coronary artery disease
- Previous coronary artery bypass graft surgery
- Significant left main stem coronary disease
- Chronic total occlusion in the target vessel
- Contraindication to percutaneous coronary intervention or drug-eluting stent implantation
- Contraindication to antiplatelet therapy
- Contraindication to adenosine infusion
- Severe valvular disease
- Severe LV systolic impairment
- Severe respiratory disease
- Life expectancy less than 2 years, pregnancy, unable to consent
Key Trial Info
Start Date :
January 16 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2023
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04280575
Start Date
January 16 2020
End Date
May 1 2023
Last Update
September 22 2023
Active Locations (2)
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1
Essex Cardiothoracic Centre, Basildon and Thurrock University Hospitals NHS Trust
Basildon, Essex, United Kingdom
2
Imperial College Healthcare NHS Trust
London, United Kingdom, W12 0HS