Status:
UNKNOWN
Next-generation Sequencing of Colorectal Cancer Somatic Cells to Guide Genetic Susceptibility Gene Mutations Screening.
Lead Sponsor:
Fudan University
Conditions:
Hereditary Colorectal Cancer
Eligibility:
All Genders
18+ years
Brief Summary
This is a prospective, single-center, clinical study.This study is to evaluate the feasibility of genetic susceptibility screening based on the detection of tumor tissue mutations by a NGS panel.
Detailed Description
In this study, gene mutation profiling was performed on primary tissue samples from colorectal cancer patients who met relevant clinical screening criteria, unearthing suspected germline pathogenic mu...
Eligibility Criteria
Inclusion
- A biopsy proven histological diagnosis of colorectal carcinoma.
- ≥ 18 years of age on the day of signing informed consent.
- Patients must meet the relevant clinical screening standards, such as the Amsterdam Standard (I / II),etc.
- Patients need to provide tumor tissue samples and matched peripheral blood (leukocyte) samples.
Exclusion
- History of other malignant tumors(except for cervical carcinoma in situ, basal or squamous cell skin cancer which has been fully treated).
- There is no detailed histopathological report to judge the nature of the lesions.
- Any social or psychological problems, etc., which are judged by the researcher to be unsuitable for the study.
- For various reasons, the baseline samples (tumor tissue samples, peripheral blood samples) were incomplete.
- Patients who are unwilling or unable to follow the research program for long-term and regular follow-up in current medical institutions.
- Failure to complete the follow-up within 2 years.
Key Trial Info
Start Date :
June 20 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2022
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04280666
Start Date
June 20 2019
End Date
December 31 2022
Last Update
February 21 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
270 Dongan Road, Fudan University Shanghai Cancer Center
Shanghai, China, 200032