Status:
UNKNOWN
Genetic Polymorphisms of ABCB11 and ABCB4 in Women With Intrahepatic Cholestasis of Pregnancy (ICP) and in Their First Degree Relatives
Lead Sponsor:
Alexandra Hospital, Athens, Greece
Conditions:
Cholestasis of Pregnancy
Eligibility:
FEMALE
18-50 years
Brief Summary
To assess the occurrence of 11 SNP's in ABCB11 and ABCB4 genes in Greek women with ICP compared with healthy pregnant women. Moreover, these genetic polymorphisms will be examined in their first-degre...
Detailed Description
Introduction: ICP is commolnly manifested in the 2nd and especially in the 3rd trimester of pregnancy. Pathogenesis of ICP is multifactorial implicating genetic, environmental and hormonologic factors...
Eligibility Criteria
Inclusion
- pregnant women with ICP
Exclusion
- women with known hepatic disease ( HBV, HCV, HIV, HEV, Autoimmune Hepatitis, Drug induced liver injury, cirrhosis)
- women with pregnancy related liver disease (pre-eclampsia, acute fatty liver of pregnancy or HELLP syndrome)
Key Trial Info
Start Date :
January 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 31 2022
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04281082
Start Date
January 1 2018
End Date
January 31 2022
Last Update
September 2 2021
Active Locations (1)
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1
Alexandra General Hospital
Athens, Greece, 11528