Status:
RECRUITING
Markers to Evaluate the Efficacy of PH-based Regimen as a Neoadjuvant Therapy for Operable HER2 Positive Breast Cancer
Lead Sponsor:
Fudan University
Conditions:
HER2-positive Breast Cancer
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
This study is to explore the markers in early prediction of the efficacy of pre-operative pertuzumab plus trastuzumab (PH) combined with chemotherapy for early stage or locally advanced human epiderma...
Detailed Description
This study is to evaluate the correlation between early changes in multiple markers and pathological complete response in breast and lyphm nodes (tpCR) in patients with HER2-positive breast cancer rec...
Eligibility Criteria
Inclusion
- Female or male, presenting for the first time with operable breast cancer, who had not received any previous treatment for an invasive malignancy.
- Primary tumor greater than (\>) 2 cm in diameter.
- Age ≥ 18 years and \< 70 years.
- Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to (\</=) 1.
- Baseline left ventricular ejection fraction (LVEF) greater than or equal to (\>/=) 55%
- Availability of tumor tissue specimen after surgery.
- Participants agree to undergo a core needle biopsy for genomic testing and organoid drug sensitivity assay.
- Histologically proven diagnosis of breast cancer.
- Patients have HER2-positive disease. HER2-positive disease was defined as follows: disease which overexpresses HER-2 by immunohistochemistry (IHC) 3+ and/or has HER2 amplification according to fluorescence in situ hybridization (FISH).
- Had hormonal receptors (ER and PgR) assessed.
- Signed informed consent.
- Able to comply with the protocol.
Exclusion
- Metastatic disease (Stage IV) or bilateral breast cancer.
- Any previous systemic therapy (including chemotherapy, immunotherapy, HER2 targeted agents, and antitumor vaccines) for cancer, or radiation therapy for cancer.
- Prior breast or non-breast malignancy within 5 years prior to study entry.
- Inadequate bone marrow, renal, or liver function
- History or evidence of cardiovascular condition
- Severe, uncontrolled systemic disease
- Participants with poorly controlled diabetes or with evidence of clinically significant diabetic vascular complications.
- Pregnancy or breast-feeding women.
- Participants who received any investigational treatment within 4 weeks of study start.
- Participants with known infection with human immunodeficiency virus (HIV), hepatitis B virus, or hepatitis C virus.
- Current chronic daily treatment with corticosteroids (dose \>10 mg methylprednisolone or equivalent \[excluding inhaled steroids\]).
- Known hypersensitivity to any of the study drugs or excipients
Key Trial Info
Start Date :
April 21 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 30 2030
Estimated Enrollment :
94 Patients enrolled
Trial Details
Trial ID
NCT04281641
Start Date
April 21 2020
End Date
April 30 2030
Last Update
May 4 2020
Active Locations (1)
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1
Shanghai Cancer Center, Fudan University
Shanghai, Shanghai Municipality, China, 200000