Status:
RECRUITING
Effects of a Specific Substance in Smokers
Lead Sponsor:
Oregon Health and Science University
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Smoking
Eligibility:
All Genders
21-40 years
Phase:
NA
Brief Summary
Although rates of cigarette use are declining, the proportion of nondaily smokers is rising, particularly among young adults. Among young adults, nondaily smoking is associated with negative health co...
Detailed Description
The purpose of this study is to investigate the neurobiological mechanisms associated with cigarette use in young nondaily smokers (ages 21-25). Nondaily smokers experience fewer symptoms of cigarette...
Eligibility Criteria
Inclusion
- Participants must be 21-40 years old
- Right-handed
- Fluent in English
- Report smoking cigarettes or e-cigarettes 1-27 days in the past month
- Report binge drinking based on NIAAA criteria (5 or more drinks per occasion for males, 4 or more drinks per occasion for females) at least 1 time in the past 90 days without adverse incident
Exclusion
- Seeking treatment for substance use (e.g. nicotine or alcohol use)
- Moderate or Severe Nicotine Dependence
- Current alcohol use disorder
- Illicit substance use other than marijuana use in the past year
- Marijuana use more than 10 times in the past year
- Major neurological or medical illness - Significant head trauma - Current use of medication affecting the central nervous system
- MRI contraindications (e.g. irremovable metal on the body or pregnancy)
Key Trial Info
Start Date :
February 25 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04281979
Start Date
February 25 2020
End Date
December 31 2025
Last Update
July 28 2025
Active Locations (1)
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1
Oregon Health and Science University
Portland, Oregon, United States, 97239