Status:
COMPLETED
The Effect of Restrictive Fluid Management on Cardiac Function and Glycocalyx Degradation
Lead Sponsor:
Karolinska Institutet
Conditions:
Septic Shock
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The study aims to compare the effects of restrictive fluid management on cardiac dysfunction and vascular integrity in septic shock patients. To achieve this, patients with septic shock according to S...
Detailed Description
This study is a substudy to the larger CLASSIC-trial that aims to investigate restrictive and standard fluid therapy in treating septic shock. Adult patients with septic shock according to the Sepsis-...
Eligibility Criteria
Inclusion
- \- Patients with septic shock according to the Sepsis-3 criteria who have received at least 1 L of IV fluid in the 24 hours before screening
Exclusion
- Patients who have had septic shock for more than 12 hours at the time of screening
- Patients who have life-threatening bleeding
- Patients with acute burn injury \>10% of the body surface area
- Pregnant patients
- Patients in whom consent cannot be obtained
Key Trial Info
Start Date :
February 2 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 22 2022
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT04282252
Start Date
February 2 2020
End Date
April 22 2022
Last Update
April 3 2025
Active Locations (1)
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1
Södersjukhuset
Stockholm, Sweden, 11883