Status:
COMPLETED
A Retrospective Cohort Study: The Influence of MTHFR C677T and A1298C on the High-dose Methotrexate-Related Toxicities in Pediatric Patients With Non-Hodgkin Lymphoma
Lead Sponsor:
Sun Yat-sen University
Conditions:
Pediatric NHL
Eligibility:
All Genders
Up to 18 years
Brief Summary
We hypothesized that polymorphism MTHFR C677T and A1298C should be associated with HD-MTX-related toxicities in children with NHL. Therefore, we aimed to retrospectively explore their relationships in...
Detailed Description
INTRODUCTION: Non-Hodgkin lymphoma (NHL), the fourth most common malignancy across the pediatric age spectrum, is a heterogeneous group of lymphoid malignancies. In children, NHL comprises four main w...
Eligibility Criteria
Inclusion
- patients who were:
- Aged ≤ 18 years old；
- Diagnosed as the four main types of NHL, including lymphoblastic lymphoma (LBL), Burkitt's lymphoma (BL), anaplastic large cell lymphoma (ALCL), diffuse large B-cell lymphoma (DLBCL);
- Treated with HD-MTX therapy at the dose of 5g/m2;
- Genotyped by PCR following Sanger with respect to MTHFR C677T and A1298C
- With complete medical records.
Exclusion
- patients who were:
- Aged \>18 years old；
- Diagnosed as cancer types other than the four main types of NHL;
- Treated with no HD-MTX therapy or at the dose other than 5g/m2;
- Not genotyped by PCR following Sanger with respect to MTHFR C677T and A1298C
- With incomplete medical records .
Key Trial Info
Start Date :
March 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2019
Estimated Enrollment :
93 Patients enrolled
Trial Details
Trial ID
NCT04283955
Start Date
March 1 2014
End Date
March 1 2019
Last Update
February 25 2020
Active Locations (1)
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1
Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China, 510060