Status:
UNKNOWN
Perioperative Continuation of Metformin Therapy in Patients With Typ 2 Diabetes Mellitus Undergoing Non-cardiac Surgery
Lead Sponsor:
Kepler University Hospital
Conditions:
Hyperglycemia
Metformin
Eligibility:
All Genders
18-99 years
Phase:
PHASE4
Brief Summary
Evaluation of the effect of peri-operative continuation of oral metformin therapy on the incidence of perioperative hyperglycemia compared to standard preoperative cessation of oral metformin therapy ...
Detailed Description
Surgical procedures cause metabolic stress and can impair glucose control especially in patients with diabetes mellitus, which often results in peri-operative hyperglycemia. Peri-operative hyperglycem...
Eligibility Criteria
Inclusion
- Age 18-99 years
- Diabetes Mellitus Typ 2
- Oral metformin therapy
- Non cardiac-surgery
- Informed consent
Exclusion
- Insulin therapy
- Ambulatory surgery
- Preoperative therapy with glucocorticoids (prednisolon or equivalent ≥ 5mg/day for more than 7 days)
- Planned postoperative ICU-stay
- Advanced renal insufficiency (eGFR \< 45ml/kg/min)
- Advanced liver cirrhosis or failure (Child-Pugh B or C)
- Alcohol abuse
- Pregnancy,
- Perioperative administration of contrast dye
Key Trial Info
Start Date :
February 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2021
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT04284722
Start Date
February 1 2020
End Date
April 1 2021
Last Update
February 26 2020
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