Status:
UNKNOWN
Role of aGVHD Biomarkers on aGVHD Risks
Lead Sponsor:
Chinese PLA General Hospital
Conditions:
GVHD,Acute
Biomarker
Eligibility:
All Genders
Up to 65 years
Brief Summary
To establish risk rating criteria of biological protein marker, determine the role and consistency of aGVHD biomarkers in aGVHD diagnosis and aGVHD prognosis, and evaluate the the impact on non-relaps...
Detailed Description
1. To establish standard risk rating criteria of aGVHD biomarkers; 2. To verify the role of aGVHD biomarkers monitored in predicting aGVHD risks; 3. To determine the correlation between aGVHD biomarke...
Eligibility Criteria
Inclusion
- Diagnosed with hematological diseases.
- Have underwent first allogeneic hematopoietic stem cell transplantation (allo-HSCT) from any donor source using bone marrow, peripheral blood stem cells, or cord blood for hematologic malignancies.
Exclusion
- recipients of second allogeneic stem cell transplant.
- pregnant or breast-feeding women.
- Serum creatinine \> 2.0 mg/dL or creatinine clearance \< 40 mL/min measured or calculated by Cockroft-Gault equation.
- human immunodeficiency virus infection
- active hepatitis b virus, hepatitis C virus infection and need antivirus treatment.
- Subjects with evidence of relapsed primary disease, or subjects who have been treated for relapse after the allo-HSCT was performed, or graft rejection.
- allergic history to Janus kinase inhibitors.
- Severe organ dysfunction unrelated
- Any condition that would, in the investigator's judgment, interfere with full participation in the study, including administration of study drug and attending required study visits; pose a significant risk to the subject; or interfere with interpretation of study data.
Key Trial Info
Start Date :
July 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2023
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT04284904
Start Date
July 1 2018
End Date
December 31 2023
Last Update
February 26 2020
Active Locations (1)
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1
Chinese PLA General Hospital
Beijing, Beijing Municipality, China, 100853