Status:
RECRUITING
Brain Connections for Arm Movement After Stroke
Lead Sponsor:
VA Office of Research and Development
Collaborating Sponsors:
VA Pittsburgh Healthcare System
University of Pittsburgh
Conditions:
Stroke
Brain Disease
Eligibility:
All Genders
45-90 years
Phase:
NA
Brief Summary
The purpose of this study is to use Transcranial Magnetic Stimulation (TMS) while subjects are making reaching movements in a robotic arm device in order to discover how different brain areas control ...
Detailed Description
The general objective of this application is to study reorganization of network interactions following a common type of subcortical stroke (i.e. internal capsule) with mechanistic studies using noninv...
Eligibility Criteria
Inclusion
- Inclusion Criteria (control participants):
- Be 45-90 years of age
- Have adequate language and neurocognitive function to participate in training and testing
- Be medically stable to participate in the study
- Be English speaking
- Inclusion Criteria (participants with stroke):
- Be 45-90 years of age
- Clinically defined, unilateral, hemiparetic stroke with radiologic exclusion of other possible diagnosis
- Stroke onset at least 6 months before enrollment
- Subcortical stroke (ex: internal capsule, deep white matter of posterior frontal lobe)
- Present with mild to moderate arm dysfunction
- Be medically stable to participate in the study
- Be English speaking
Exclusion
- (for both groups)
- Unable to give informed consent
- Have a serious complicating medical illness that would preclude participation
- Contractures or orthopedic problems limiting range of joint motion in the potential study arm or other impairments that would interfere with the study activities
- Visual loss such that the subject would not be able to see the test patterns on the robot computer monitor
- Unable to comply with requirements of the study
- Enrollment in another greater-than-minimal risk study
- Presence of medical condition or implant that prevents safe administration of TMS or MRI
- Pregnancy
Key Trial Info
Start Date :
January 10 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2027
Estimated Enrollment :
76 Patients enrolled
Trial Details
Trial ID
NCT04286516
Start Date
January 10 2020
End Date
June 1 2027
Last Update
June 13 2025
Active Locations (1)
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1
VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA
Pittsburgh, Pennsylvania, United States, 15240