Status:
COMPLETED
SWISH Trial (Strategies for Weaning Infants on Supportive High Flow)
Lead Sponsor:
Cardiff and Vale University Health Board
Conditions:
Respiratory Disease
Bronchiolitis, Viral
Eligibility:
All Genders
4-12 years
Phase:
NA
Brief Summary
Bronchiolitis is a common type of chest infection that tends to affect babies and young children under a year old. In older children and adults, the same viruses that cause bronchiolitis lead to the '...
Detailed Description
Bronchiolitis is the commonest respiratory infection in infancy leading to hospital admission. 46 per 1000 infants were admitted to hospital with bronchiolitis in England in 2011 and more recent studi...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Clinical diagnosis of bronchiolitis
- Age \>4 weeks and \<12 months
- Needs HFNC respiratory support in a ward setting for more than 12 hours
- Exclusion criteria:
- Requirement for imminent intubation and ventilation or having received mechanical ventilation during the current hospital admission
- Requirement for imminent CPAP support
- Pre-existing or concomitant, non-viral respiratory infection
- Pre-existing respiratory disease
- Ready to wean high-flow after \<12 hours of its initiation
- Weight \>10kg
- Low level of consciousness
- Apnoeas\*
- Cyanotic heart disease
- Basilar skull fracture
- Upper airway obstruction
- Craniofacial malformations
- Infants on home oxygen
- Ex-premature infants (born at \<32 weeks gestation)
Exclusion
Key Trial Info
Start Date :
October 6 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2025
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04287959
Start Date
October 6 2023
End Date
June 1 2025
Last Update
June 8 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Children's Hospital for Wales
Cardiff, United Kingdom, CF14 4XW