Status:
UNKNOWN
Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
Himalayan Rescue Association
Conditions:
High Altitude Pulmonary Edema
Non-Invasive Positive Pressure Ventilation
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Trial of Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema
Detailed Description
Patients in the Everest area will assessed for evidence of acute HAPE. Subjects will be randomized and assigned to standard care options or treatment with Non-Invasive Positive Pressure Ventilation.
Eligibility Criteria
Inclusion
- Healthy adults (age 18-80)
- Travel through Pheriche, Nepal
- Diagnosis of HAPE by symptoms, vital signs, and lung ultrasound
Exclusion
- History of chronic respiratory conditions (asthma, COPD, ILD)
- Concomitant pneumonia or aspiration, cardiomyopathy, congestive heart failure
- Kidney disease
- Neurologic disorder
- Cognitive disorder
- Temporary altered mental status
- Use of phosphodiesterase inhibitors or nifedipine prior to diagnosis of HAPE
- Age under 18 or over 80
- Pregnancy
Key Trial Info
Start Date :
March 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2021
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT04288219
Start Date
March 1 2020
End Date
June 1 2021
Last Update
September 3 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Himalayan Rescue Association
Kathmandu, Nepal