Status:
UNKNOWN
Effects of Oxytocin on Cognitive and Reactive Fear
Lead Sponsor:
University Hospital, Bonn
Conditions:
Oxytocin
Eligibility:
MALE
18-40 years
Phase:
PHASE1
Brief Summary
The study examines the (sub)regional specificity of anxiolytic oxytocin (OXT) effects on emotional face processing and reactive and cognitive fear. Preliminary data indicate that the Receptor for Adva...
Detailed Description
So far, no study examined selective oxytocin (OXT) effects on reactive (midbrain periaqueductal gray (PAG), central amygdala (CeA), hypothalamus, and the midcingulate cortex (MCC)) and cognitive fear ...
Eligibility Criteria
Inclusion
- RAGE polymorphism (-374 T/A: rs1800624; TT vs. TA/AA)
- healthy male volunteers
- right handed
Exclusion
- current psychiatric illness
- current psychiatric medication or psychotherapy
- MRI contraindication (e.g. metal in body, claustrophobia)
Key Trial Info
Start Date :
December 13 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2021
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04292444
Start Date
December 13 2019
End Date
May 1 2021
Last Update
March 12 2020
Active Locations (1)
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1
Department of Psychiatry and Medical Psychology
Bonn, Germany, 53105