Status:
UNKNOWN
TMS in Preclinical and Prodromal AD: Modulation of Brain Networks and Memory
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Alzheimer Disease
Mild Cognitive Impairment
Eligibility:
All Genders
60-85 years
Phase:
NA
Brief Summary
The purpose of this study is to assess the effects of non-invasive brain stimulation on memory in cognitively unimpaired older adults and in patients amnestic mild cognitive impairment (aMCI) due to A...
Eligibility Criteria
Inclusion
- Between the ages of 60-85
- All participants will be native English speakers
- Willing and able to consent to the protocol and undergo imaging and neuropsychological testing at the specified time points
- Participants with aMCI will be asked to bring a study partner to all visits
- Only patients with very mild or mild cognitive impairment (CDR 0.5 or CDR 1) will be included in the prodromal AD cohort
Exclusion
- History of head trauma involving loss of consciousness or alteration in consciousness
- Another major neurologic or psychiatric condition
- Known presence of a structural brain lesion (e.g. tumor, cortical infarct)
- Any contraindication to MRI, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body
- Longstanding premorbid history (i.e. longer than 10 years) of alcohol or substance abuse with continuous abuse up to and including the time that the symptoms leading to clinical presentation developed
- Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the study protocol.
- Unwilling to return for follow-up, undergo neuropsychological testing, TMS, and MR imaging
Key Trial Info
Start Date :
March 2 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2024
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04294888
Start Date
March 2 2020
End Date
March 1 2024
Last Update
March 12 2020
Active Locations (1)
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1
Massachuetts General Hospital
Charlestown, Massachusetts, United States, 02129