Status:
UNKNOWN
Comparison of the Effects of Fentanyl, Oxycodone, Butorphanol on Gastrointestinal Function
Lead Sponsor:
The First Affiliated Hospital with Nanjing Medical University
Conditions:
Cervix Neoplasms
Endometrial Cancer
Eligibility:
FEMALE
40-65 years
Phase:
NA
Brief Summary
Postoperative ileus (POI) is a transient loss of coordinated peristalsis precipitated by surgery and exacerbated by opioid pain medication.So,how to provide patients with ideal analgesia without affec...
Detailed Description
Background: Patients often experience pain after gynecological laparoscopy. However, the use of opioid analgesia after surgery may increase the incidence of postoperative ileus (POI). Postoperative il...
Eligibility Criteria
Inclusion
- patients who were scheduled for laparoscopic hysterectomy from W\&C BRANCH HOSPITAL OF JIANGSU PROVINCE HOSPITAL
- American Society of Anesthesiologists (ASA) physical status classification 1 to 2,
- Women aged 40-65
- Weight 50-80 kg
Exclusion
- History of opioids abuse and allergy and contraindication to opioid drugs
- bronchial asthma; coronary heart disease; severe hypertension; diabetes mellitus;
- hepatic, and renal dysfunction (glutamyl aminotransferase\> 40U or aspartate aminotransferase\> 35U; urea nitrogen\> 8.2 μmol / L, creatinine\> 133 μmol / L),
- History of brain damage or psychiatric disease
- Patients with coagulopathy (PT\> 17 seconds or activated partial thromboplastin time (APTT)\> 47 seconds);
- pregnant or lactating women;
- Those with long-term constipation;
- History of digestive diseases;
- history of gastrointestinal disease (peptic ulcer disease, Crohn's disease, or ulcerative colitis)
- Participants in other drug trials in the past three months. （11）After randomization and allocation, patients were withdrawn if laparoscopy was converted to open surgery or if they required reinvestigation for postoperative bleeding.
Key Trial Info
Start Date :
March 2 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2020
Estimated Enrollment :
105 Patients enrolled
Trial Details
Trial ID
NCT04295109
Start Date
March 2 2020
End Date
July 31 2020
Last Update
April 24 2020
Active Locations (1)
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1
The First Affiliated Hospital with Nanjing Medical University
Nanjing, Jiangsu, China, 210029