Status:
COMPLETED
Brain Imaging Changes Following Proton Therapy for Pediatric Primary Central Nervous System and Base of Skull Tumors
Lead Sponsor:
Mayo Clinic
Conditions:
Malignant Central Nervous System Neoplasm
Malignant Skull Base Neoplasm
Eligibility:
All Genders
Up to 21 years
Brief Summary
This trial gathers information from patients with primary central nervous system or base of skull tumors that receive proton beam therapy and see if certain imaging techniques can help detect radiatio...
Detailed Description
PRIMARY OBJECTIVE: I. To establish linear energy transfer (LET)-based models as early predictors for white matter changes on magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) sequen...
Eligibility Criteria
Inclusion
- Patients must have histologically confirmed central nervous system of skull base tumors
- Patient is going to undergo central nervous system (CNS) or base of skull proton beam therapy
Exclusion
- Patients who have received prior therapeutic radiotherapy to the primary brain tumor site
- Patients who are unable to maintain follow-up through the Phoenix Children's Hospital and Mayo Clinic Arizona
Key Trial Info
Start Date :
January 21 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 23 2023
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT04296617
Start Date
January 21 2019
End Date
October 23 2023
Last Update
May 17 2024
Active Locations (1)
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1
Mayo Clinic in Arizona
Scottsdale, Arizona, United States, 85259