Status:
SUSPENDED
Evaluation of Regional Anticoagulation With Citrate in Extended Hemodialysis
Lead Sponsor:
University of Sao Paulo General Hospital
Collaborating Sponsors:
InCor Heart Institute
Hospital do Cancer, Sao Paulo
Conditions:
Hemodialysis Complication
Acute Kidney Injury
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
Data on regional citrate anticoagulation in patients with acute kidney injury (AKI) treated by hybrid or extended dialysis are scarce and heterogeneous. The path batch system (Genius®) or the proporti...
Detailed Description
The investigators conduct an open label randomized clinical trial with cross-over between the groups. The study will be performed in all the intensive care units (ICU) at the Heart Institute and the C...
Eligibility Criteria
Inclusion
- All patients with acute kidney injury admitted to the intensive care unit and candidates for extended dialysis (renal replacement therapy)
- Age over 18 years.
Exclusion
- Acute liver failure
- Hemorrhagic stroke in the last 30 days
- Patients with platelet levels below 20,000/mm3
- Active bleeding requiring transfusion (two or more red blood cell packs within 24 hours)
Key Trial Info
Start Date :
February 12 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2022
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04297839
Start Date
February 12 2019
End Date
July 31 2022
Last Update
October 5 2021
Active Locations (1)
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1
University of São Paulo Medical School
São Paulo, Brazil, 01246903