Status:
COMPLETED
Effect of Physiologic Hyperglucogonemia on Adipocyte Metabolism
Lead Sponsor:
The University of Texas Health Science Center at San Antonio
Collaborating Sponsors:
South Texas Veterans Health Care System
Conditions:
Insulin Sensitivity
Eligibility:
All Genders
18-50 years
Phase:
EARLY_PHASE1
Brief Summary
Purpose/Objectives: To investigate the effect of hyperglucagonemia on insulin action, particularly on adipose tissue. Research Design/Plan: Normal glucose tolerant subjects will be studied. Study sub...
Detailed Description
Visit 1 Screening: All subjects will be performed indirect calorimetry to determine rates of energy expenditure and glucose/lipid oxidation for 40 minutes prior to all other procedures to obtain a fas...
Eligibility Criteria
Inclusion
- Fasting Glucose \< 100 mg/dl
- HbA1C \< 5.7%
- 2-h OGTT value \< 140 mg/dl
- Good general Health as determined by medical history, physical exam, screening lab tests, urinalysis, and EKG.
- Weight Stable (±3 lbs) over the preceding 3 months
- ages from 18-50
- Male/Female
- BMI from 23-28 kg/m2 -
Exclusion
- Subjects who participate in an excessively heavy exercise program.
- Subjects taking any medication known to affect glucose tolerance will be excluded.
- Cannot be pregnant
- Hyper sensitive to glucagon
- \-
Key Trial Info
Start Date :
February 5 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 15 2023
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT04300049
Start Date
February 5 2018
End Date
November 15 2023
Last Update
October 21 2024
Active Locations (2)
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1
South Texas Veterans Health Care Center
San Antonio, Texas, United States, 78229
2
The University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229