Status:
UNKNOWN
Measures of Mitochondria Dysfunction in PD
Lead Sponsor:
University of Washington
Collaborating Sponsors:
Michael J. Fox Foundation for Parkinson's Research
Conditions:
Parkinson Disease, Mitochondrial
Eligibility:
All Genders
65-85 years
Brief Summary
This study evaluates metabolic and functional parameters in the skeletal muscle of Parkinson's disease patients for comparison to a set of healthy age-matched controls.
Detailed Description
The goal of this study is to identify the unique signature of bioenergetic markers and mitochondrial (dys)function in muscle of individuals with PD, who are 65-85 of age, read and speak English, have ...
Eligibility Criteria
Inclusion
- Age 65-85 years.
- Ability to attend a 3-hour study visit in Seattle, WA.
- Ability to read and speak English.
- Hoehn \& Yahr Stage 2-3. (bilateral disease, not severely disabled.)
Exclusion
- Any contra-indication to magnetic resonance imaging
- A history of epilepsy, stroke, brain surgery, or structural brain disease.
- The presence of other serious illnesses
- Current or recent enrollment in a clinical trial involving an investigational product or device.
- Supplementation with NAD, nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), and other nutraceuticals designed to target NAD for 30 days prior to baseline study visit.
- Current drug or alcohol use or dependence.
- Inability/unwillingness to provide informed consent. (e.g. diagnosis of dementia, confusion about study goals or participation.)
- Acute infection (e.g. upper respiratory, dermal) in the previous 30 days.
- Right limb tremor or dyskinesia that cannot be comfortably controlled for 90 minutes.
Key Trial Info
Start Date :
February 24 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2021
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04300608
Start Date
February 24 2020
End Date
November 1 2021
Last Update
November 5 2020
Active Locations (1)
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1
University of Washington
Seattle, Washington, United States, 98109