Status:
UNKNOWN
The Synergistic Effect of Hypoglycemic Index Diet on Refractory Schizophrenia
Lead Sponsor:
Shanghai Jiao Tong University School of Medicine
Conditions:
Refractory Schizophrenia
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
This experiment was conducted to investigate the improvement of hypoglycemic index diet (LGIT) as a potential new intervention scheme for treatment-resistant schizophrenia, and to further explore the ...
Detailed Description
A low glycemic index diet (LGIT) is a modification of a ketogenic diet (KD) that includes low carbohydrate, medium protein, and high fat intake.It is a potential new intervention for refractory schizo...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- ①Meet the diagnostic criteria of schizophrenia in icd-10, and score ≥4 in any item of p1-7 in PANSS scale.
- ② Meet the diagnostic criteria for treatable schizophrenia: in the past 5 years to three drugs and the appropriate dose and course of antipsychotic drugs (three drugs at least two chemical structures are different) poor response; Adverse reactions of patients who cannot tolerate antipsychotic drugs; Even with adequate maintenance treatment or preventive treatment, the patient still relapses or deteriorates.
- Age 18-65.
- Exclusion criteria:
- Patients with the following diseases: fatty acid transport or oxidation defects, ketone body synthesis or decomposition defects, mitochondrial diseases, serious liver diseases, pyruvate carboxylase defects, porphyria, carnitine deficiency, some immunodeficiency diseases, organic acid urine; ② Patients with bleeding tendency, severe hypertension and severe heart, liver, lung, kidney failure, severe epilepsy patients; ③ Serious history of alcohol and drug abuse, addiction; ④ Extremely excited restless patients;Patients using implantable electronic devices.
Exclusion
Key Trial Info
Start Date :
September 24 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 31 2022
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04302636
Start Date
September 24 2019
End Date
May 31 2022
Last Update
November 15 2021
Active Locations (1)
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1
Shanghai Huangpu District Mental Health Center
Shanghai, Shanghai Municipality, China, 200023