Status:
COMPLETED
Renin as a Biomarker of Haemodynamic Normalisation
Lead Sponsor:
South West Sydney Local Health District
Conditions:
Shock
Eligibility:
All Genders
18+ years
Brief Summary
Study design Observational, single centre, prospective cohort study Planned sample size 100 participants Inclusion criteria The study will evaluate a cohort of participants meeting the following incl...
Detailed Description
The renin-angiotensin aldosterone system (RAAS) is integral to cardiovascular homeostasis and involved in the regulation of blood pressure, electrolyte balance and intravascular volume. Renin is produ...
Eligibility Criteria
Inclusion
- Admission to ICU after elective and emergency cardiac surgery following cardiopulmonary bypass
- Age 18 years and above
- Arterial, central venous catheters and pulmonary arterial catheters are inserted preoperatively
Exclusion
- Age under 18 years
- Known pregnancy
- Arterial, central venous catheters and pulmonary arterial catheters that are not indicated as part of routine care
- End stage renal disease requiring renal replacement therapy
- Participants with known Child Pugh A cirrhosis or greater
- Treatment with any steroids
- Participant is not expected to live beyond the day after the day of admission
Key Trial Info
Start Date :
March 24 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 12 2021
Estimated Enrollment :
104 Patients enrolled
Trial Details
Trial ID
NCT04303455
Start Date
March 24 2020
End Date
March 12 2021
Last Update
March 24 2021
Active Locations (1)
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1
Dr Wajid Khan
Sydney, New South Wales, Australia, 2170