Status:
COMPLETED
Effect of Non-surgical Periodontal Treatment on Cardiovascular Risk Markers
Lead Sponsor:
Mahidol University
Conditions:
Coronary Heart Disease
Periodontitis
Eligibility:
All Genders
35-70 years
Brief Summary
The research question was to investigate whether non-surgical periodontal therapy could reduce cardiovascular risk markers in Coronary heart disease (CHD) patients.
Detailed Description
CHD patients or non-CHD with or without periodontitis were included. They were provided with non-surgical periodontal therapy (NSPT). Periodontal parameters and cardiovascular risk markers were measur...
Eligibility Criteria
Inclusion
- non-CHD or CHD (at least 50% diameter stenosis in at least one coronary artery and clinically stable with absence of any potentially confounding inflammatory conditions for at least 6 months)
- had at least 14 natural teeth excluding third molars
Exclusion
- received anticoagulant drugs
- had chronic conditions (e.g. diabetes mellitus, rheumatoid arthritis, malignancy, autoimmune disease) or acute conditions (e.g. trauma, surgery) or medications known to affect systemic inflammatory markers (e.g. antibiotics, immunosuppressive, contraceptives) within 3 months
- pregnancy or lactation
- presence or history of other infections
- periodontal treatment within 6 months
- tooth extractions within 2 months prior to the study.
Key Trial Info
Start Date :
April 6 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 20 2020
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT04305171
Start Date
April 6 2018
End Date
February 20 2020
Last Update
March 12 2020
Active Locations (3)
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1
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University
Ratchathewi, Bangkok, Thailand, 10400
2
Department of Medicine, Rajavithi Hospital
Ratchathewi, Bangkok, Thailand, 10400
3
Mahidol University Faculty of Dentistry
Ratchathewi, Bangkok, Thailand, 10400