Status:
RECRUITING
Characterization of Vaginal, Urinary and Fecal Microbiomes in Women with Recurrent Urinary Tract Infections
Lead Sponsor:
Hadassah Medical Organization
Conditions:
Urinary Tract Infections
Menopause
Eligibility:
FEMALE
Brief Summary
The objectives are to evaluate whether variations in vaginal and/or urinary and/or fecal microbiome predispose postmenopausal women to recurrent cystitis. This will be explored using comparison of mic...
Detailed Description
Patients and age-matched control subjects will be recruited from the Urogynecology clinic in Hadassah Mt Scopus and the gynecology clinic, respectively. After assessment of inclusion and exclusion cr...
Eligibility Criteria
Inclusion
- Patients' inclusion criteria:
- Menopausal status
- Two or more documented, culture-positive infections in the last six months or ≥3 infections in the last year Patients' exclusion criteria
- Neurogenic bladder condition
- Known immunodeficiencies
- Usage of antibiotics or probiotics within the previous month
- Known renal calculi or anatomic malformations
- Control subjects- Inclusion criteria:
- Menopausal status
- Sterile urine cultures, normal urinalysis, and negative sexually-transmitted PCR urine assay
- Control subjects- Exclusion criteria:
- \- A prior history of UTIs or other urologic abnormalities.
Exclusion
Key Trial Info
Start Date :
August 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04305808
Start Date
August 1 2021
End Date
December 30 2025
Last Update
March 19 2025
Active Locations (1)
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1
Hadassah Medical Center
Jerusalem, Jerusalem, Israel, 9765422