Status:
UNKNOWN
Ovarian Fragmentation Study (Crespo Medical Team)
Lead Sponsor:
Equipo Juana Crespo
Conditions:
Ovarian Failure
Premature Ovarian Failure
Eligibility:
FEMALE
18-45 years
Phase:
NA
Brief Summary
This is a study designed to validate Kawamura´s theory and investigation of activation of primordial follicles through ovarian cortex fragmentation. Our aim is to evaluate embryo quality following thi...
Eligibility Criteria
Inclusion
- Abdominal surgery need for fertility cause.
- Bad embryo quality (\>2 cycles with \< 1 embryo A-B quality. With:
- A. Poor ovarian responders (previous ≤ 3 retrieved metaphase II oocytes) in a conventional cycle.
- B. Decreased ovarian reserve (antral follicle count (AFC) ≤ 5 or antiMullerian hormone (AMH) ≤ 0.5 ng/mL).
- C.Premature ovarian insufficiency according to:
- Patients \< 40 years old.
- At least 1 year of amenorrhea.
- Follitropin serum levels (FSH) \>35 IU/ml in two serum samples separated by at least 1 month.
- Estradiol serum levels (E2) \< 20 pg/mL.
Exclusion
- Clinical/ultrasonographical signs of severe endometriosis ( or endometrioma).
- Age over 45 years (EMC)
- Previous ovarian/pelvic surgery. Unilateral oophorectomy.
- Body Mass Index \> 30
- Previous gonadotoxic treatment.
- Genito-urinary tract malformations.
- Inform consent unsigned.
Key Trial Info
Start Date :
May 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2021
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04306185
Start Date
May 1 2020
End Date
March 1 2021
Last Update
March 12 2020
Active Locations (1)
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1
Ander Morales Vicente
Valencia, Spain, 46000