Status:
COMPLETED
CHESS Criteria for Varices Screening in Compensated Advanced Chronic Liver Disease (CHESS2001/APPHA2001)
Lead Sponsor:
Hepatopancreatobiliary Surgery Institute of Gansu Province
Collaborating Sponsors:
LanZhou University
Tianjin Second People's Hospital
Conditions:
Compensated Advanced Chronic Liver Disease
Varices Needing Treatment
Eligibility:
All Genders
18-75 years
Brief Summary
Variceal hemorrhage is the serious complication in patients with compensated advanced chronic liver disease (cACLD). To evaluate the bleeding risk of varices in cACLD, esophagogastroduodenoscopy (EGD)...
Detailed Description
Variceal hemorrhage is the serious complication in patients with compensated advanced chronic liver disease (cACLD). To evaluate the bleeding risk of varices in cACLD, esophagogastroduodenoscopy (EGD)...
Eligibility Criteria
Inclusion
- age 18-75 years;
- confirmed cirrhosis based on liver biopsy or clinical findings;
- without decompensated events (e.g. ascites, bleeding, or overt encephalopathy);
- scheduled to undergo esophagogastroduodenoscopy, and liver stiffness measurement;
- estimated survival time\>24 months, and model for end-stage liver disease score\<19, and without liver transplant;
- with written informed consent.
Exclusion
- contradictions for esophagogastroduodenoscopy;
- accepted primary prevention (non-selective beta blockers or endoscopic variceal ligation);
- Child-Pugh score\>9;
- time frame between liver stiffness and esophagogastroduodenoscopy\>14 days;
- diagnosed as hepatocellular carcinoma or other hepatobiliary and pancreatic malignancies;
- splenectomy or hepatectomy;
- portal vein thrombosis or cavernous transformation of portal vein;
- pregnancy or unknown pregnancy status.
Key Trial Info
Start Date :
March 18 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 17 2023
Estimated Enrollment :
2000 Patients enrolled
Trial Details
Trial ID
NCT04307264
Start Date
March 18 2020
End Date
March 17 2023
Last Update
April 25 2023
Active Locations (15)
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1
Ankang Central Hospital
Ankang, China
2
Beijing Tsinghua Changgung Hospital
Beijing, China
3
the Seventh Medical Center of PLA General Hospital
Beijing, China
4
Dalian Sixth People's Hospital
Dalian, China