Status:
UNKNOWN
Efficacy of Ivabradine in Patient With Both Persistent Atrial Fibrillation and Heart Failure With Reduce Ejection Fraction
Lead Sponsor:
Chun-Yao Huang
Conditions:
Atrial Fibrillation
Ivabradine
Eligibility:
All Genders
20-90 years
Phase:
PHASE3
Brief Summary
Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice. Previous studies have shown that rate control strategy in AF is non-inferior to rhythm control strategy, in ter...
Eligibility Criteria
Inclusion
- The patient with persistent or permanent atrial fibrillation(24hr ECG) with HFrEF and HFmrEF.
- After maximal tolerance dose beta-blocker(Bisoprolol 20mg/day，Carvedilol 50mg/day) or intolerant to beta-blocker the resting heart rate from ECG is still faster than 100 or resting heart rate from ECG is greater than 80 but still with symptoms of short of breath and palpitation.
- Stable heart rhythm medication.(no change of medication in recently one week)
- Age 20 to 90 years old.
- The subject must be an adult who can read himself/herself and walk independently.
Exclusion
- Used medication with interaction with digoxin : Clarithromycin, Erythromycin, Azithromycin, ritonavir, lopinavir/ritonavir, Doxycycline, Minocycline, tetracycline。
- Used medication with interaction with ivabradine: voriconazole, posaconazole, fluconazole, Ombitasvir, Dasabuvir, Carbamazepine, Enzalutamide, Fosphenytoin, Mitotane, Phenobarbital, Phenytoin, Rifampicin
- Cardiogenic shock.
- History of symptomatic bradycardia.
- Renal insufficiency:eGFR\<30 ml/min/1.73m2
- Pregnancy
- Heart failure due to congenital heart
- Severe hypotension(\<90/50mmHg)
Key Trial Info
Start Date :
August 26 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2020
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04308031
Start Date
August 26 2018
End Date
December 31 2020
Last Update
March 13 2020
Active Locations (1)
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1
Taipei Medical University Hospital
Taipei, Taiwan