Status:
WITHDRAWN
Does rTMS Induce Synaptic Plasticity?
Lead Sponsor:
Davidzon, Guido, M.D.
Collaborating Sponsors:
Stanford University
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-70 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to utilize the radioactive positron emission tomography (PET) tracer \[11C\]UCB-J to investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on synap...
Detailed Description
The objective of this project is to discover the neural mechanisms by which Major Depressive Disorder (MDD) is treated, so that we may gain insights into its pathophysiology, as well as to develop new...
Eligibility Criteria
Inclusion
- 18-70 years in age
- U.S. Veteran
- Diagnosis of MDD
- On a stable medication regimen for at least two weeks prior to testing
- Stable social environment and housing to enable regular attendance at clinic visits
- Ability to undergo cognitive testing, clinical assessments, and PET/MR scans
- Stable medical health
- Will undergo rTMS treatment for MDD at the VA Palo Alto
- Able to complete a PET-MR scan without the use of sedation
Exclusion
- Active substance use within three months of testing
- IQ \< 70
- Major medical neurological illness or significant head trauma
- Pregnancy or breastfeeding
- Contraindication to MR scanning, including magnetic-resonance incompatible metal or hardware including pacemakers, cochlear implants, and bullets near a critical organ
- Weight \> 350 lbs or a large body habitus that MR scanner cannot accommodate
- History of or current claustrophobia
- Inability to comply with basic study requirements such as following directions and punctuality
- Acute or unstable chronic medical illness that would affect participation or compliance with study procedures, e.g. unstable angina
- Unstable psychiatric symptoms that precludes consistent participation in the study, e.g. active current suicidal intent or plan, severe psychosis
- Inability to undergo PET/MR scan, e.g. claustrophobia, presence of ferromagnetic objects in subject's body
Key Trial Info
Start Date :
December 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2025
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04311619
Start Date
December 1 2019
End Date
February 1 2025
Last Update
December 2 2024
Active Locations (2)
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1
VA Palo Alto Health Care System
Palo Alto, California, United States, 94304
2
Stanford University
Stanford, California, United States, 94305