Status:
UNKNOWN
Effectiveness of Regenerative Endodontics Therapy for Single-rooted Mature Permanent Tooth With Pulp Necrosis
Lead Sponsor:
Southern Medical University, China
Collaborating Sponsors:
Shenzhen Hospital, Southern Medical University
Conditions:
Pulp Necrosis
Eligibility:
All Genders
10-59 years
Phase:
NA
Brief Summary
This study is to evaluate the effectiveness of regenerative endodontics therapy in single-rooted permanent teeth with pulp necrosis，and compare the clinical efficacy of platelet rich fibrin (PRF) and ...
Detailed Description
Regenerative endodontics therapy (RET), based on the principles of tissue engineering, manipulates stem cells, scaffold, and bioactive growth factors to achieve the functional reconstruction of pulp t...
Eligibility Criteria
Inclusion
- Intended to participate with this study, and provide informed assent/consent.
- Aged 10 and 59 years.
- At least one mature permanent teeth diagnosed as pulp necrosis with or without periapical lesion, and CBCT showed the teeth has single root and single root canal.
Exclusion
- Allergic to any medications or materials necessary to complete the procedures.
- The teeth with severe coronal defect, of which pulp space is needed for post/core final restoration.
- Non-restorable teeth.
- The teeth with root fracture or vertical root fractures.
- Concurrent signs of other pathological root resorption.
- Patients with periodontitis.
- Patients with dental dysplasia or other oral genetic disorders.
- Women who are pregnant or lactating, or women who plan to become pregnant in the subsequent 2 years.
- Patients with dental phobia.
- Patients with mental disorders.
- Patients with a history of systemic diseases that may alter immune function.
- Patients with medical conditions and/or receiving medications that would affect patients' body's ability of healing or blood clotting.
- Participants who are participating in or had participated in other clinical studies within the prior 3 months.
Key Trial Info
Start Date :
March 16 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2024
Estimated Enrollment :
346 Patients enrolled
Trial Details
Trial ID
NCT04313010
Start Date
March 16 2020
End Date
June 30 2024
Last Update
March 23 2020
Active Locations (3)
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1
Nanfang Hospital, Southern Medical University
Guangzhou, China
2
Stomatological Hospital, Southern Medical University
Guangzhou, China
3
Shenzhen Hospital, Southern Medical University
Shenzhen, China