Status:
COMPLETED
Duloxetine for PHN
Lead Sponsor:
Beijing Tiantan Hospital
Collaborating Sponsors:
China-Japan Friendship Hospital
Tianjin Medical University Second Hospital
Conditions:
Postherpetic Neuralgia
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
In this study, the investigators aim to investigate the preventive efficacy of prophylactic oral duloxetine during acute herpes zoster on postherpetic neuralgia and its safety.
Detailed Description
Postherpetic neuralgia is a common complication of herpes zoster. Several interventions have been investigated for the treatment of postherpetic neuralgia, however, there is a lack of preventive inter...
Eligibility Criteria
Inclusion
- ages more than 50 years;
- diagnosed with uncomplicated acute herpes zoster;
- presents with vesicles within 72 hours;
- has an average pain score of at least 40/100 mm on a visual analog scale (VAS, 0 = no pain, 100 = worst possible pain, at opposite ends of a 100-mm line).
Exclusion
- refuses to participate or to provide written informed consent;
- Zung Self-Rating Depression Scale raw score of more than 50 points;
- herpes zoster that involves with head, neck, ocular, mucous membrane, cranial nerve, or central nervous system;
- has hemorrhagic or necrotizing lesions, satellite lesions, abnormal vesicles or acute retinal necrosis;
- has been on immunosuppressive therapy or mono- or multi-pharmacotherapy that involves any tricyclic antidepressant, valacyclovir, duloxetine or cytotoxic medications before acute HZ onset;
- has been diagnosed with hepatic, renal or immune dysfunction;
- during pregnancy or breastfeeding at the time;
- hypersensitivity to the study drugs;
- has contraindications to valacyclovir or duloxetine;
- HZ vaccinated.
Key Trial Info
Start Date :
March 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 16 2023
Estimated Enrollment :
750 Patients enrolled
Trial Details
Trial ID
NCT04313335
Start Date
March 1 2021
End Date
May 16 2023
Last Update
January 9 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China, 100050