Status:
COMPLETED
Metabolomics Profiling Research of Human Cerebrospinal Fluid in Aging Process
Lead Sponsor:
Chang Gung Memorial Hospital
Conditions:
Aging
Metabolites
Eligibility:
All Genders
20+ years
Brief Summary
Perform quantitative metabolomics on human cerebrospinal fluid (CSF) samples and establish the first human CSF Metabolome Database of aging process in Taiwan.
Detailed Description
Metabolomics is new science based on metabolite profiles in biofluids and tissues, which under bioinformatics approaches and analyses could help to characterize metabolomic status of CSF in aging proc...
Eligibility Criteria
Inclusion
- Aging groups:
- . Above 20 years.
- . No history of central nerve system injury and neurologic illness
- . ASA≦II
- . Written informed consent from the patient
- Aged-related neurodegenerative diseases group:
- . Above 60 years of age
- . Medical record proved the history of Parkinsonism or Alzheimer disease
- . ASA≦III
- . Written informed consent from the patient or guardian by statute.
Exclusion
- patient refuses to sign informed consent
- patients with coagulopathy, systemic infective disease and severe liver and renal function impairment
- patients with spine or brain tumor and CNS disease
- the presence of severe and/or uncontrolled and/or unstable medical disease within 12 months prior to study (e.g. acute pancreatitis, stroke, liver cirrhosis, congestive heart failure, and systemic immune disorder etc
- Concurrent participation or planning to participate in another interventional clinical trial (Concurrent participation in an observational trial allowed)
Key Trial Info
Start Date :
August 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 31 2021
Estimated Enrollment :
190 Patients enrolled
Trial Details
Trial ID
NCT04315038
Start Date
August 1 2019
End Date
July 31 2021
Last Update
January 31 2022
Active Locations (1)
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1
Chang Gung Memorial Hospital
Taoyuan District, Taiwan, 333