Status:
UNKNOWN
Early Postoperative CRRT After Liver Transplantation in ACLF Patients With Overt HE
Lead Sponsor:
Third Affiliated Hospital, Sun Yat-Sen University
Conditions:
Acute-On-Chronic Liver Failure
Hepatic Encephalopathy
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Pretransplant hepatoencephalopathy (HE) markedly impacts recipient outcomes after liver transplantation. Intraoperative CRRT showed benefits but feasibility was much concerned. This study aims to obse...
Detailed Description
Hepatoencephalopathy (HE) is a common severe decompensation in end stage liver diseases and resulted to the need of liver transplantation (LT). Pretransplant HE markedly impacts recipient outcomes aft...
Eligibility Criteria
Inclusion
- Liver transplant recipients who meet all of the following criteria will be enrolled
- Pre transplant liver failure: Total bilirubin over 171μmol/L and prothrombin activity (PTA)\<40%;
- Overt hepatic encephalopathy(HE): Grade II or higher HE according West Haven classification;
- HE associated with acute liver failure (Type A) or cirrhosis complicated with portal hypertension and/or portal systemic shunts (Type C)
Exclusion
- Patients with a previous history of kidney-related diseases and glomerular filtration rate \<30 millilitre per minute;
- Patients with acute renal failure need CRRT before transplantation;
- Patients newly developed acute renal failure need CRRT at the time of randomization;
- Retransplantation or multiple-organs transplantation;
- Any ischemic or hemorrhagic stroke co-morbidity;
- Hemodynamic instability requiring fluid resuscitation or very high dose of vasopressors;
- Extremely moribund patients with an expected life expectancy of less than 24 hours.
Key Trial Info
Start Date :
June 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2022
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT04317222
Start Date
June 1 2020
End Date
August 31 2022
Last Update
March 23 2020
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.