Status:
ACTIVE_NOT_RECRUITING
The Human Stress Response in a Simulated ED Setting
Lead Sponsor:
University of Arkansas
Conditions:
Stress Physiology
Stress Reaction
Eligibility:
All Genders
21-55 years
Phase:
NA
Brief Summary
Stress is important for health. As emergency departments (EDs) are often stressful places, a better understanding of the human stress response is important for understanding how and why patients respo...
Detailed Description
Aim 1: Determine the feasibility and acceptability of an ED-relevant stressor task as compared to a standard social stressor task. The investigators hypothesize that an ED-relevant stressor task will ...
Eligibility Criteria
Inclusion
- Healthy adult
- 21-55 years of age
- Self-reported recent history of meth use that meets DSM-5 criteria for current meth use disorder
- Have been previously inside an ED as either a patient or visitor
- Able to construct a stressful mental script of ED experiences
- Body mass index (BMI) \< 30
- Ability to read and understand English
- If matched control, no lifetime history of any recreational or non-prescribed drug use.
Exclusion
- Eating/drinking/taking drugs or alcohol the morning before the experiment
- If smoker, not smoking the morning before the experiment
- Subjective or objective signs of intoxication or withdrawal from any substance
- History of any serious medical condition such as cardiovascular, endocrine, neurologic (seizures), or hepatic disease
- Pregnancy
- History of any mental illness
- Hypertensive (\>150/90) or abnormal EKG at screening
- Use of any daily medication
- Any recent night shift work in the last 4 weeks
- Any travel across time zones in the last 14 weeks
- Participation in a similar study in the past year
- Refusal to allow videotaping
Key Trial Info
Start Date :
August 26 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04317482
Start Date
August 26 2020
End Date
December 1 2026
Last Update
October 10 2025
Active Locations (1)
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1
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States, 72205