Status:
COMPLETED
Breath Analysis in Patients With Suspected Sarcoidosis: The VOCs-IS Study
Lead Sponsor:
Manchester University NHS Foundation Trust
Collaborating Sponsors:
Norfolk and Norwich University Hospitals NHS Foundation Trust
Conditions:
Pulmonary Sarcoidosis
Eligibility:
All Genders
18+ years
Brief Summary
Sarcoidosis is a chronic condition which predominantly affects the lungs and lymph glands within the chest, however, may affect any organ within the body. At the present time, very little is known as ...
Detailed Description
Sarcoidosis is chronic condition which can affect any organ within the body, however frequently involves the lungs and thoracic lymph nodes. The exact cause of the disease remains uncertain and it is ...
Eligibility Criteria
Inclusion
- Participants with Suspected Sarcoidosis:
- Age \>18 years
- Suspected pulmonary sarcoidosis undergoing investigations for diagnosis, staging and treatment consideration or discussion at a designated interstitial lung disease multidisciplinary meeting (this includes participants with stage I disease characterised by the presence of hilar or mediastinal lymphadenopathy)
Exclusion
- Significant respiratory co-morbidity where the primary major respiratory diagnosis is not sarcoidosis
- Current smoker or ex-smoker (having ceased smoking \<3 months duration)
- Extra-pulmonary sarcoidosis without any evidence of pulmonary involvement (characterised by normal pulmonary function tests and no radiological evidence of thoracic sarcoidosis on HRCT or chest radiography)
- Inability to provide written consent
- Self-reported lower respiratory tract infection, or treatment with antibiotics for a lower respiratory tract infection or any other infection within the previous 4 weeks
- Healthy Volunteers:
- Inclusion Criteria:
- Age \>18 - 70 years
- Normal spirometry
Key Trial Info
Start Date :
October 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 8 2021
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT04318392
Start Date
October 1 2018
End Date
October 8 2021
Last Update
November 2 2021
Active Locations (2)
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1
Norfolk and Norwich University Hospital NHS Foundation Trust
Norwich, Norfolk, United Kingdom, NR4 7UY
2
Wythenshawe Hospital, Manchester University NHS Foundation Trust
Manchester, United Kingdom, M23 9LT