Status:
COMPLETED
Early Diagnosis of Mortality Using Admission CT Perfusion in Severe Traumatic Brain Injury Patients (ACT-TBI Study)
Lead Sponsor:
University of Manitoba
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Conditions:
Traumatic Brain Injury
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Background: Severe traumatic brain injury (TBI) is a principal cause of post-injury hospitalization, disability, and death throughout the world. TBI is the leading cause of death and disability among ...
Detailed Description
Objectives of the ACT-TBI study: In patients with severe TBI, 1. To validate admission CTP features of brain death, relative to the clinical examination outcome, for characterizing early in-hospital...
Eligibility Criteria
Inclusion
- At least 18 years old
- Severe head injury with the activation of the trauma code
- GCS score ≤ 8 after initial resuscitation
- On mechanical respiratory ventilation at the time of imaging
Exclusion
- No known GCS after initial resuscitation
- Known pregnancy
- Known contraindication to CT contrast agent, e.g.,allergy or anaphylactic reaction
- Known end-stage renal disease stage 4-5 (eGFR \< 30 mL/min/1.73 m2)
Key Trial Info
Start Date :
July 23 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 2 2023
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04318665
Start Date
July 23 2020
End Date
August 2 2023
Last Update
January 19 2024
Active Locations (4)
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1
Health Sciences Centre
Winnipeg, Manitoba, Canada, R3A 1R9
2
QEII Health Scienecs Centre
Halifax, Nova Scotia, Canada, B3K 4N1
3
The Ottawa Hospital
Ottawa, Ontario, Canada, K1Y 4E9
4
Centre hospitalier de l'Université de Montréal (CHUM)
Montreal, Quebec, Canada, H2X 0C1