Status:
COMPLETED
Netosis in Determination of Respiratory Infection Severity
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Respiratory Infection
Eligibility:
All Genders
18+ years
Brief Summary
The study aims to evaluate the prognostic value of alveolar and blood NETosis in patients under mechanical ventilation and treated for an acute low-respiratory tract infection. The main outcome is the...
Detailed Description
Neutrophils are the first line of defense against infectious injury. Among the numerous mechanisms involving the immune system, neutrophil extracellular traps (NETs) have been recently described as an...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- A/ For all subjets:
- Be \>/= 18 years of age on day of signing informed consent;
- Affiliated to the french social security - welfare system in France.
- B/ Inclusion criteria for acute respiratory failure patients:
- admitted to the ICU for acute respiratory failure requiring mechanical ventilation within the first 24 hours after admission and suspected to suffer from an infectious pneumonia, according to the following criteria:
- recent fever;
- acute respiratory failure signs (dyspnea, polypnea \> 30 cycles/min, hypoxemia PaO2\<65 mmHg);
- pulmonary focal signs of auscultation;
- evocative signs in chest radiography or chest TDM.
- C/ Inclusion criteria for control patients:
- \- admitted to the ICU for post-operative management of vascular surgery.
- Exclusion Criteria:
- A/ For all subjets:
- pregnancy,
- nosocomial pneumonia,
- no social health insurance,
- neutropenia of any cause;
- patient refusal.
- B/ Exclusion criteria for acute respiratory failure patients:
- \- no mechanical ventilation within the first 24 hours after admission to the ICU.
Exclusion
Key Trial Info
Start Date :
June 7 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 3 2023
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04318691
Start Date
June 7 2022
End Date
January 3 2023
Last Update
March 16 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Service de médecine intensive réanimation, Hôpital Ambroise Paré, APHP
Boulogne-Billancourt, France, 92100