Status:
ACTIVE_NOT_RECRUITING
Sodium Storage in Singaporeans
Lead Sponsor:
Jens Titze
Collaborating Sponsors:
National Heart Centre Singapore
Conditions:
Healthy
Hypertension
Eligibility:
All Genders
21+ years
Brief Summary
The overarching hypothesis of this study is that the kidney and the skin form an integrative network for water conservation, where Na+ storage is utilized to prevent body water loss, even at the expen...
Detailed Description
Cardiovascular disease (CVD) occurs with increasing age and is the leading cause of death worldwide. A causal relationship between salt and CVD, although well established in animal models, has been di...
Eligibility Criteria
Inclusion
- Participants from the Biobank (Molecular and Imaging Studies of Cardiovascular Health and Disease) cohort in Singapore, who agreed to be contacted for further studies
- Male and female patients older than 21 years
- Willingness to participate and ability to provide informed consent
Exclusion
- Patients with exclusion criteria for the MRI, such as:
- implanted devices (surgical clips, heart pacemakers or defibrillators, cochlear implants)
- iron-based tattoos
- any other pieces of metal or devices that are not MR-Safe anywhere in the body
- patients who exhibit noticeable anxiety and/or claustrophobia into the MRI scanner
- Pregnant women
- Diagnosis of heart failure NYHA classes III and IV
- Impaired renal function with eGFR\<45 ml/min or proteinuria \> 0.5 g/24h
- Liver disease with cirrhosis (Child-Pugh class C) or hypoalbuminemia
- Peripheral oedema as assessed by the investigator
- Active cancer
- Patients who have received an organ or bone marrow transplant
- Patients who have had major surgery in the past 3 months
- Patients who have severe comorbid conditions likely to compromise survival or study participation
- Unwillingness or other inability to cooperate
Key Trial Info
Start Date :
July 2 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2035
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT04319068
Start Date
July 2 2019
End Date
December 31 2035
Last Update
August 2 2024
Active Locations (2)
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1
National Heart Centre Singapore
Singapore, Singapore, 169609
2
Duke-NUS Medical School
Singapore, Singapore, 169857