Status:
TERMINATED
Alteration of Blood-Brain-Barrier Permeability at Loss of Consciousness in Delirious Patients Recorded With Direct-Current Electroencephalography (ACDC)
Lead Sponsor:
Charite University, Berlin, Germany
Conditions:
Delirium
Eligibility:
All Genders
18-110 years
Brief Summary
With this trial we aim to characterize the intraoperative signatures of the Direct-Current-Electroencephalogram (DC-EEG) of elderly patients developing a PostOperative Delirium (POD) compared to patie...
Detailed Description
In order to study the intraoperative DC-EEG signatures of elderly patients coupled with lab data to evaluate the role of the age-dependent blood-brain barrier (BBB) dysfunction in general anesthesia a...
Eligibility Criteria
Inclusion
- Patients aged \>70 years OR between 18 and 30
- Planned operation time \>1 hour
- Expected hospital treatment period of 5 days,
- Anesthesia induction, anesthesia maintenance with either Propofol or an inhalative anesthetic agent as Sevoflurane or Desflurane,
- The ability to give informed consent
Exclusion
- Age under 18 or between 31 and 69
- Patients with a history of neurological or psychiatric disorders
- Planned neurosurgery
- Current medication of tranquilizers / antidepressants
- Isolation of patients with multi-resistant Bacteria
- Inability of the patients to speak and/or read German
- Intraoperative use of ketamine, N²O, Etomidate or Dexmedetomidine
- Participation in a prospective interventional trial
Key Trial Info
Start Date :
August 10 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 11 2021
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT04320082
Start Date
August 10 2020
End Date
November 11 2021
Last Update
May 7 2025
Active Locations (1)
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1
Department of Anesthesiology and Operative Intensive Care Medicine (CCM/CVK), Charité - Universitätsmedizin Berlin
Berlin, Germany, 13353