Status:
WITHDRAWN
Evaluation of Sepsis-induced Immunosuppression Base on QuantiFERON Monitor® in Septic Shock
Lead Sponsor:
Centre Hospitalier Universitaire de Nice
Conditions:
Septic Shock
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
QuantiFERON Monitor® is an immunological test evaluating the nonspecific cellular response by measuring interferon gamma (IFNγ) secretions after T-cell and natural killer lymphocyte stimulation. This...
Detailed Description
A sepsis-induced immunosuppression phase has recently been characterized and has been associated with worse outcomes as well as increased healthcare costs. Furthermore, a marked suppression of the imm...
Eligibility Criteria
Inclusion
- Patient hospitalized in intensive care and intensive care at Nice University Hospital and presenting with septic shock (defined by the presence of sepsis, the need for a vasopressor to maintain a MAP\> 65mmHg and hyperlactatemia\> 2mmol / l)
- Free and express informed consent signed by the patient or the confidential counselor in case of impossibility (deferred consent of the patient as soon as his condition allows it)
- Age\> 18 years old
- Affiliated to a social security scheme
Exclusion
- Pregnant woman Patient under the age of 18
- Patient under guardianship or curatorship or placed in detention
- Patient with congenital or previously acquired immune deficiency
- Patient on prior immunosuppressive treatment
Key Trial Info
Start Date :
July 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2022
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04320394
Start Date
July 1 2020
End Date
July 1 2022
Last Update
July 27 2023
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