Status:
COMPLETED
Short Term Results of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure
Lead Sponsor:
KTO Karatay University
Collaborating Sponsors:
Istanbul Medipol University Hospital
Conditions:
Anal Fissure Chronic
PRP
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
Autologous PRP currently has many uses in surgical and medical therapy. Compared with other regenerative therapies, PRP is easy-to-prepare, low-cost, and does not require complex equipment. The use of...
Detailed Description
. Chronic anal fissures are mucosal ulcers in the anal canal distal to the dentate line and most often present with severe pain and bleeding during defecation. The symptoms of chronic anal fissures pe...
Eligibility Criteria
Inclusion
- between 18 and 65 years of age with painful defecation of at least 2 months duration and diagnosed with anal fissure between January and October 2019 were included.
- The diagnosis of chronic anal fissure required :
- the presence of internal sphincter muscle fibers in the base of the fissure
- hypertrophic anal papillae on digital rectal examination
Exclusion
- Patients with physical examination findings that did not meet the definition of chronic anal fissure
- with painful defecation for less than 2 months,
- atypical fissure location or multiple anal fissures away from the midline
- inflammatory bowel disease
- cancer
- history of trauma
- tuberculosis
- immune suppression
- sexually transmitted disease
- a disease possibly associated with a fissure
- a history of anal surgery
- previous treatment for anal fissure
- current pregnancy .
Key Trial Info
Start Date :
January 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 2 2021
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT04320498
Start Date
January 1 2019
End Date
January 2 2021
Last Update
April 7 2022
Active Locations (1)
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1
Karatay Medicana Üniversitesi
Konya, Turkey (Türkiye)