Status:
RECRUITING
Study of Circulating Monocytes in Patients With Ischemic Vascular Disease
Lead Sponsor:
UConn Health
Conditions:
Myocardial Infarction
Stroke, Ischemic
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this research study is to discover the functions of circulating white blood cells, called monocytes, and associated circulating substances in heart attack and ischemic stroke patients. ...
Detailed Description
The research objective here is to perform a pilot study in determining the level of such monocytes in MI/stroke patients at various times after the acute ischemic event. As controls, both stable coron...
Eligibility Criteria
Inclusion
- STEMI Patients: Men and women aged 18 years and over, with symptoms, physical signs and ECG changes characteristic of STEMI.
- NSTEMI Patients: Men and women aged 18 years and over, with symptoms, physical signs and ECG changes characteristic of NSTEMI.
- Stable CAD Patients: men and women aged 18 years and older with coronary artery disease proven by prior MI history, angiography or stress test but without any unstable angina or acute coronary syndrome.
- Ischemic Stroke Patients: Men and women aged 18 years and over, with symptoms, physical signs and CT/MRI changes characteristic of ischemic stroke.
- Healthy Controls: Men and women aged 18 years and over, without heart failure, coronary disease, hypertension, diabetes or other chronic diseases. Control subjects will be recruited from within the community of UConn Health via advertisement.
Exclusion
- Subjects who are unable to give informed consent (with the exception of the ischemic stroke arm patients, see Protocol Design below) and pregnant subjects.
- Subjects who had any history of embolic, ischemic or hemorrhagic stroke within the last 12 months.
Key Trial Info
Start Date :
December 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2027
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT04321512
Start Date
December 1 2013
End Date
December 1 2027
Last Update
August 14 2025
Active Locations (1)
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1
University of Connecticut Health Center
Farmington, Connecticut, United States, 06030