Status:
TERMINATED
Proactive Protection With Azithromycin and hydroxyChloroquine in Hospitalized Patients With COVID-19
Lead Sponsor:
Chronic Obstructive Pulmonary Disease Trial Network, Denmark
Conditions:
Virus Diseases
Infection Viral
Eligibility:
All Genders
Phase:
PHASE2
Brief Summary
This study explores whether patients acutely hospitalized may have shorter hospitalization and fewer admittances at Intensive Care Units by treatment with azithromycin and hydroxychloroquine.
Detailed Description
In the ongoing coronavirus pandemic, COVID-19, that arose in Wuhan China, there is still sparse data in the course, risk of various complications, and in particular how patients who are hospitalized a...
Eligibility Criteria
Inclusion
- Patient admitted to a Danish emergency department, lung medical department or medical department
- Age \>18 years
- Hospitalized \<48 hours
- Positive COVID-19 test/diagnosis during the hospitalization
- Signs informed consent
Exclusion
- If the patient uses \> 5 LO2/min at time of recruitment
- Known intolerance/allergy to azithromycin or hydroxychloroquine or hypersensitivity to quinine or 4-aminoquinolinderivates
- Pregnancy
- Breastfeeding
- Neurogenic hearing loss
- Psoriasis
- Retinopathy
- Maculopathy
- Changes in vision field
- Severe liver disease other than amoebiases
- Severe gastrointestinal, neurological or haematological disorders
- eGFR \< 45 ml/min/1.73m2
- Clinically significant cardiac conduction disorders/arrhythmias or prolonged QTc interval
- Myasthenia Gravis
- Uses Digoxin
- Glucose-6-phosphate dehydrogenase deficiency
- Porphyria
- Hypoglycemia at any time since hospitalization
- Severe mental illness which significantly impedes cooperation
- Severe linguistic problems that significantly impedes cooperation
- Treatment with sickle alkaloids
Key Trial Info
Start Date :
April 6 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 2 2021
Estimated Enrollment :
117 Patients enrolled
Trial Details
Trial ID
NCT04322396
Start Date
April 6 2020
End Date
February 2 2021
Last Update
June 29 2021
Active Locations (8)
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1
Aalborg Sygehus
Aalborg, Denmark
2
Bispebjerg Hospital
Copenhagen, Denmark
3
Herlev-Gentofte Hospital
Copenhagen, Denmark
4
Hvidovre Hospital
Copenhagen, Denmark