Status:
UNKNOWN
Clinical Characteristics and Treatment of Chest Tightness Variant Asthma
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University
Conditions:
Asthma
Chest Syndrome
Eligibility:
All Genders
14-80 years
Phase:
NA
Brief Summary
Asthma, abbreviation for bronchial asthma, is one of the common chronic airways disease that threatens human health. Typical symptoms of asthma are recurrent wheezing, shortness of breath, chest tight...
Eligibility Criteria
Inclusion
- all subjects agreed to participate, understand the project, observe the use of drugs, agree to follow-up, and signed informed consent;
- the age of more than 14 and less 80 years old, gender and ethnicity are not limited;
- the duration time was more than 6 months,and chest tightness was the only complaint, without breathing, short of breath, chronic cough;
- no wheezing;
- a diagnosis of asthma supported by one or more other characteristics:
- bronchial provocation test positive;
- improvement in forced expiratory volume at one second (FEV1) of more than 12% and 200 mL after inhaled salbutamol;
- variability in diurnal peak expiratory flow (PEF) of more than 10% for one day during one week.
- bronchodilator and glucocorticoid treatment is effective;
- exclude the following diseases by the corresponding doctors: coronary heart disease, myocarditis, heart failure, gastroesophageal reflux disease(GERD), neuromuscular disease, and mental disease.
Exclusion
- can not cooperate with related inspection or for other reasons;
- patients with chronic obstructive pulmonary disease, interstitial pneumonia, active tuberculosis, community acquired pneumonia, lung cancer, bronchiectasis, cor pulmonale, pulmonary embolism, and accompanied with serious systematic disease (such as coronary heart disease, myocarditis, heart failure, gastroesophageal reflux disease, neuromuscular disease, etc);
- history of drug abuse, alcohol abuse or anesthesia or with a history of mental illness (schizophrenia, obsessive-compulsive disorder, depression) and against personality, motivation, suspicious, or other emotional or mental issues that may affect participation in the study;
- taking part in other drug clinical trial project, or drop out less than 3 months;
- during pregnancy, lactation women;
- obvious abnormal of High Resolution CT.
Key Trial Info
Start Date :
June 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2022
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT04322422
Start Date
June 1 2020
End Date
December 31 2022
Last Update
May 12 2020
Active Locations (33)
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1
Beijing Chao-Yang Hospital
Beijing, Beijing Municipality, China
2
China-Japan Friendship Hospital
Beijing, Beijing Municipality, China
3
Xinqiao Hospital，Third Military Medical University
Chongqing, Chongqing Municipality, China
4
The Second Affiliated Hospital，Fujian Medical University
Fuzhou, Fujian, China