Status:
COMPLETED
Gene Expression of Endocannabinoid System in Episodic and Chronic Migraine Patients
Lead Sponsor:
IRCCS National Neurological Institute "C. Mondino" Foundation
Collaborating Sponsors:
Ministry of Health, Italy
Conditions:
Chronic Migraine
Eligibility:
All Genders
18+ years
Brief Summary
Preclinical and clinical evidence suggests a role for the dysregulation of endocannabinoid system (ES) in migraine pain, particularly in subjects with chronic migraine. The gene expression of ES comp...
Detailed Description
Migraine is a neurovascular disease whose pathophysiology is far from being completely clarified. This is mainly due to the complex mechanisms that underlie migraine attack as well as its recurrence. ...
Eligibility Criteria
Inclusion
- Inclusion Criteria for subjects with Episodic Migraine (EM):
- satisfaction of the diagnostic criteria for migraine without aura according to the International Headache Classification 3rd edition (ICHD-3);
- an episodic pattern of migraine for at least 10 years without any period of chronification.
- Exclusion Criteria:
- any systemic diseases, psychiatric disorders or any other clinically significant conditions.
- Inclusion criteria for patient with chronic migraine with medication overuse (CM-MO):
- satisfaction of the ICHD-3 diagnostic criteria for chronic migraine and for one of the subtypes of medication overuse headache;
- a history of stable chronification for at least 5 years.
- Exclusion Criteria:
- any systemic diseases, psychiatric disorders or any other clinically significant conditions.
- Inclusion Criteria for healthy controls (CT):
- no history of migraine or other primary headaches;
- Infrequent tension-type headache episodes.
- Exclusion Criteria:
- any systemic diseases, psychiatric disorders or any other clinically significant conditions;
- any type of painkiller in the 24 hours prior to the blood sampling.
Exclusion
Key Trial Info
Start Date :
December 12 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2019
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT04324710
Start Date
December 12 2017
End Date
December 31 2019
Last Update
March 27 2020
Active Locations (1)
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1
Ircss Mondino Foundation
Pavia, Italy, 27100