Status:
UNKNOWN
LOD vs Gn in Anovulatory PCOs Resistant to First Line Agents
Lead Sponsor:
Assiut University
Conditions:
Polycystic Ovary Syndrome
Anovulation
Eligibility:
FEMALE
18-40 years
Phase:
NA
Brief Summary
PCOS is a complex disease that is diagnosed by the presence of two of the following three: oligo/anovulation, clinical and/or biochemical hyperandrogenism, or polycystic ovaries by ultrasound . PCOS a...
Detailed Description
PCOS is a complex disease that is diagnosed by the presence of two of the following three: oligo/anovulation, clinical and/or biochemical hyperandrogenism, or polycystic ovaries by ultrasound . PCOS a...
Eligibility Criteria
Inclusion
- anovulatory polycystic ovary syndrome resistant to first line ovulation induction.
- Polycystic ovary Syndrome defined by Rotterdam's criteria 2003
- Clomiphene resistance defined as failure to ovulate with a dose of 150mg per day for 5 days for 3 cycles
- Letrozole resistance defined as failure to ovulate with a dose of 7.5 mg per day for 5 days for 3 cycles
Exclusion
- women's age \< 18 years or ≥ 40 years.
- BMI \> 40 kg/m2
- Patient with hyperprolactinaemia (serum prolactin above normal limits)
- Patients with hypogonadotropic hypogonadism (low serum FSH and LH)
- Patients with anovulation due to ovarian failure (serum FSH higher than normal limits)
- Male infertility
- Tubal abnormality, Known endometriosis, adenomyosis, uterine myomas or any other detected cause of female infertility
- History of ovarian surgery as laparoscopic ovarian drilling, ovarian cystectomy or oophorectomy
- History of pelvic radiation
- Patient recently treated with any type of induction of ovulation in the last three months.
Key Trial Info
Start Date :
December 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2022
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04325295
Start Date
December 1 2020
End Date
August 1 2022
Last Update
October 14 2020
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.