Status:
COMPLETED
Early CPAP in COVID-19 Patients With Respiratory Failure.
Lead Sponsor:
Mario Negri Institute for Pharmacological Research
Conditions:
CPAP Ventilation
COVID-19
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The study aims at clarifying whether early treatment with continuous positive airway pressure (CPAP) ventilation is able to reduce the need for intubation or death in patients visiting an emergency de...
Detailed Description
Eligible patients will be randomized to two treatment arms: current clinical practice (control arm) and early treatment with CPAP in addition to current clinical practice (experimental arm). To deal w...
Eligibility Criteria
Inclusion
- ED patients positive to or suspected of COVID-19 infection with at least one of the following symptoms:
- fever
- cough/dyspnea
- respiratory symptoms or ED arrival for respiratory reason and for whom there are the following conditions:
- SpO2 \< 95% in ambient air or positive Quick Walk Test
- PaO2/FiO2 \> 200 in ambient air or with Venturi mask, evaluated in 1 hour from ED arrival.
Exclusion
- BPCO patients
- Age \> 70 years
- Pregnant status
- Contraindications for CPAP
Key Trial Info
Start Date :
December 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 15 2022
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT04326075
Start Date
December 1 2020
End Date
December 15 2022
Last Update
December 19 2022
Active Locations (1)
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1
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Italy, 20122