Status:
COMPLETED
To Compare the Effects of Non-nutritive Sweeteners Intake in Woman With Insulin Resistance
Lead Sponsor:
University of Chile
Collaborating Sponsors:
Sociedad Chilena de Diabetes y Endocrinología (SOCHED)
Conditions:
Insulin Resistance
Hyperinsulinism
Eligibility:
FEMALE
18-35 years
Phase:
NA
Brief Summary
ABSTRACT Introduction: There is no current data about the effects of non-nutritive sweeteners (NNS) about important factors, such as the energy intake, appetite and its relationship in people with in...
Detailed Description
Protocol The experimental design was developed 3 times. Each intervention was performed separately for a minimum period of 7 days out and a maximum of 14 days, depending on the availability of the exp...
Eligibility Criteria
Inclusion
- Woman with Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) ≥ 2,5
- Body Mass Index (BMI) between 18.5 to 34.9 kg / m2
- Stable doses of oral contraceptive
- cigarette smoking \<5 units / day
- Women on metformin treatment were allowed with the requirement of discontinuation for a period of four weeks prior to study initiation.
Exclusion
- sex male
- pregnant or lactating women
- women with diseases, conditions or medications that provoke hyperinsulinism or that alter the glucidic metabolism, the postprandial hormonal response, appetite and / or satiety
- those who carry out moderate to intense physical activity three or more times a week for more than 30 minutes at a time
- those with the use of vitamin supplements or antioxidants
- Women with an allergy or aversion to the sweeteners used in the study.
Key Trial Info
Start Date :
January 15 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 25 2019
Estimated Enrollment :
33 Patients enrolled
Trial Details
Trial ID
NCT04327245
Start Date
January 15 2017
End Date
October 25 2019
Last Update
March 31 2020
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