Expanded Access for ATB200/AT2221 for the Treatment of IOPD

Status:

AVAILABLE

Expanded Access for ATB200/AT2221 for the Treatment of IOPD

Lead Sponsor:

Amicus Therapeutics

Conditions:

Pompe Disease Infantile-Onset

Eligibility:

All Genders

Up to 17 years

Brief Summary

This is an expanded access program (EAP) for eligible participants designed to provide access to ATB200/AT2221.

Detailed Description

This program is being offered on a patient by patient basis.

Eligibility Criteria

Inclusion

Patient is male or female and 0 to \< 18 years old.
Patient has a diagnosis of Pompe disease, based on documentation of GAA genotyping demonstrating variants associated with IOPD.
Patient does not currently qualify for or is unable to enroll (eg, due to location, etc) in any commercial drug-sponsored ongoing clinical trial.
Patient is currently being treated with an approved ERT and is declining (eg, worsening in motor function, respiratory function/parameters, cardiac function, etc) based on treating physician's clinical judgement.
The patient's legal guardian or representative has given informed consent (and assent when age appropriate for regional requirements) to treatment prior to administering ATB200/AT2221 in a manner consistent with all national requirements.
If of reproductive potential and sexually active, female subjects agree to use a highly effective method of contraception throughout the duration of the treatment and for up to 90 days after their last dose of ATB200/AT2221.

Exclusion

Patient has a hypersensitivity to any of the excipients in ATB200, alglucosidase alfa, or AT2221
Patient has a medical or any other extenuating condition or circumstance that may, in the opinion of the investigator and/or Amicus, pose an undue safety risk to the patient.
Concomitant use of miglitol (eg, Glyset), non-AT2221 form of miglustat (eg, Zavesca), acarbose (eg, Precose or Glucobay), voglibose (eg, Volix, Vocarb,or Volibo)

Key Trial Info

Start Date :

Trial Type :

EXPANDED_ACCESS

End Date :

Estimated Enrollment :

Patients enrolled

Trial Details

Trial ID

NCT04327973

Last Update

September 10 2025

Active Locations (4)

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Page 1 of 1 (4 locations)

UCSF Benioff Children's Hospital Oakland

Oakland, California, United States, 94609

UF Health Shands Hospital

Gainesville, Florida, United States, 32610

University Hospital of Padova

Padua, Italy