Status:
TERMINATED
Implications of Anesthetics on Sleep Consolidation
Lead Sponsor:
University of Chicago
Conditions:
Sleep
Eligibility:
All Genders
18-35 years
Phase:
PHASE4
Brief Summary
Sleep leads to consolidation of learning in humans, restoring memories that were forgotten over a waking day and protecting memories against future forgetting. Although theories of consolidation have ...
Eligibility Criteria
Inclusion
- Primary Inclusion Criteria for "Healthy" volunteers
- Age between 18-35
- Native English speaking
- No hearing or speech difficulties
- No psychiatric, neurologic, or sleep disorders
- No chronic medical conditions, as reflected below under Primary Exclusion Criteria and above in 'Medical History'
- Non-smokers (within 3 months)
- Non-users of recreational or illicit drugs (including marijuana)
- Must be willing and able to pass the drug tests (no psychoactive substances), no ingestion of alcohol or sleep-altering drugs for the 48 hours prior to the study session.
- Normal weight
- Primary Exclusion Criteria for "Healthy" volunteers
- Speech difficulties/disorders
- Hearing difficulties (including occluded or infected ear canals)
- Current hairstyles that do not allow the high-density EEG cap to make contact with the scalp (e.g., individuals with hair extensions, braids, dreadlocks or hairstyles that restrict the ability of electrodes to touch the scalp)
- Metal on/in/near their heads (including jewelry) that cannot be removed for the duration of the study
- Metal implants
- Serious abusers of alcohol or caffeine.
- Existing or suspected psychological or neurological disorders
- Pregnancy or suspected pregnancy (urine pregnancy test at visit 2)
- Chronic or transient (e.g., jet lag) problems with sleep; suspected sleep disorder
- Abnormal sleep habits, such as:
- Sleeping less than 5 hours each night
- Going to sleep before 8:00 PM or after 2:00 AM on a regular basis
- Waking up before 5:00 AM or after 10:00 AM on a regular basis.
- Currently taking medications that regulate blood pressure; a history of high blood pressure, diabetes or stroke
- Chronic smokers
- Current use of aspirin, or other medications which increase bleeding, prior to the study session.
- Known drug allergies to anesthetics or a history of an adverse reaction to anesthesia.
- Known allergy to adhesives or electrode gel
- Medication that alters sleep, cognitive function, or both
Exclusion
Key Trial Info
Start Date :
October 16 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 20 2021
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT04329091
Start Date
October 16 2020
End Date
December 20 2021
Last Update
February 24 2023
Active Locations (1)
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1
University of Chicago Medicine
Chicago, Illinois, United States, 60637