Status:
COMPLETED
Hydroxychloroquine vs. Azithromycin for Hospitalized Patients With Suspected or Confirmed COVID-19
Lead Sponsor:
Intermountain Health Care, Inc.
Collaborating Sponsors:
University of Utah
Conditions:
COVID-19
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This study will compare two drugs (hydroxychloroquine and azithromycin) to see if hydroxychloroquine is better than azithromycin in treating hospitalized patients with suspected or confirmed COVID-19.
Eligibility Criteria
Inclusion
- Adult (age ≥ 18 years)
- Confirmed OR suspected COVID-19,
- Confirmed: Positive assay for COVID-19 within the last 10 days
- Suspected: Pending assay for COVID-19 WITH high clinical suspicion
- Scheduled for admission or already admitted to an inpatient bed
Exclusion
- Allergy to hydroxychloroquine or azithromycin
- History of bone marrow transplant
- Known G6PD deficiency
- Chronic hemodialysis or Glomerular Filtration Rate \< 20ml/min
- Psoriasis
- Porphyria
- Concomitant use of digitalis, flecainide, amiodarone, procainamide, propafenone, cimetidine, dofetilide, phenobarbital, phenytoin, or sotalol
- Known history of long QT syndrome
- Current known QTc\>500 msec
- Pregnant or nursing
- Prisoner
- Weight \< 35kg
- Seizure disorder
- Severe liver disease
- Outpatient use of hydroxychloroquine for treatment of a disease other than COVID-19 OR has received more than 2 days of hydroxychloroquine or azithromycin for suspected or confirmed COVID-19
- Patient has recovered from COVID-19 and/or is being discharged from the hospital on day of enrollment.
- Treating physician refuses to allow patient participation in the study
- Unable to obtain informed consent
- Prior enrollment in this study
Key Trial Info
Start Date :
March 30 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2021
Estimated Enrollment :
85 Patients enrolled
Trial Details
Trial ID
NCT04329832
Start Date
March 30 2020
End Date
January 1 2021
Last Update
April 20 2022
Active Locations (2)
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1
Intermountain Medical Center
Murray, Utah, United States, 84107
2
University of Utah
Salt Lake City, Utah, United States, 84112